|
KMID : 0900919900140030157
|
|
Korean journal of Animal Reproduction
1990 Volume.14 No. 3 p.157 ~ p.164
|
|
|
Antifertility Effect of Passive Immunization against Progesterone Monoclonal Antibody in Mice
|
|
Kim Jong-Bae
Ko Dae-Hwan
|
|
|
Abstract
|
|
|
|
Anti-progesterone monoclonal antibody injected intraperitonially as a single dose(100mutextrm{g}) 48hours post coitum(p.c.) almostly blocked pregnancy in ICR mice. The blocking rate of pregnancy in mice treated with antibody were decreased proportionally according to dose of antibody injected ; the rate were 60%, 57% and 17% as the antibody of 10mutextrm{g}, 50mutextrm{g} and 100mutextrm{g} were injected respectively. Blood serum progesterone concentration was greatly increased(21 times) after treatment(100mutextrm{g}), by virtue of high-affinity binding by antibody in circulation of non-pregnant mice in coompared with that of control group at day 10 p.c.. The concentration was about 1.6 times higher in the pregnant mice than in the non-pregnant mice in antibody treated group. In control group, the progesterone concentration was over 7 times higher in the pregnant mice than in non-pregnant mice at day 5 p.c..
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|